Syndrome | Pathogen | Specimen | Additional information |
Lateral-flow immunochromatographic tests and small panels | |||
Systemic febrile illness | Ebola virus 1 | Whole blood | Received emergency use authorization by FDA and WHO. May not be appropriate for excluding illness in early infection. |
Dengue virus 1 | Serum | Not FDA-cleared. Highly variable diagnostic performance. Antibodies may cross-react with other flaviviruses. | |
Malaria 1 | Whole blood | Best performance characteristics for Plasmodium falciparum infections. Many versions may be available in endemic areas. | |
Gastrointestinal infections | Norovirus, rotavirus, adenovirus 1 | Stool sample | Available in the United States individually or in combination. Adenovirus rapid tests are approved for ocular specimens. |
Respiratory infections | Group A Streptococcus | Throat swab | Rapid antigen and molecular tests 2 available; both are specific but molecular tests have improved sensitivity. |
Influenza | NP or throat swab | Rapid test sensitivity 50%–70%; negative testing should not direct treatment. | |
Legionella pneumophila 1 | Urine | Only detects serogroup 1. Recommended by IDSA for patients with more severe disease. | |
Respiratory syncytial virus | NP or throat swab | Accurate antigen assays, recommended if results will affect management. | |
Streptococcus pneumoniae | Urine | Recommended by IDSA for use in certain patient populations. | |
Sexually transmitted infections | Chlamydia trachomatis and Neisseria gonorrhea 1 | Urine, vaginal swab | |
HIV | Whole blood, oral fluids | Antibody and antibody/antigen kits available. Molecular testing preferred for acute infection. | |
Treponema pallidum | Whole blood | Antibody detection, may not be appropriate for acute infections. | |
Trichomonas vaginalis | Vaginal swab | Rapid antigen testing is specific with sensitivity approximately 90%. | |
BV pathogens | Vaginal swab | Identifies increased sialidase activity, an enzyme associated with BV pathogens. | |
Multiplex molecular panels | |||
Gastrointestinal pathogens | Stool sample | Sensitive, certain positive results may be unrelated to active infection. | |
Respiratory pathogens | Includes common viruses and atypical bacteria 2 | NP swab | Pathogens may have prolonged shedding time; positive results may not rule out infection from other pathogens. |
Abbreviations: BV, bacterial vaginosis; FDA, US Food and Drug Administration; IDSA, Infectious Disease Society of America; NP, nasopharyngeal; WHO, World Health Organization. | |||
1 Not waived by Clinical Laboratory Improvement Amendments. | |||
2 Not immunochromatographic assay. |
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